曼氏血吸虫与其宿主免疫系统的相互作用受多种特异及非特异逃避机制的影响,但对这种机制的分子水平了解不多。作者认为4种蛋白与该机制有关。第一种M28,是一种分子量为28kDa的膜丝氨酸蛋白酶,具裂解补体蛋白的作用,存在于尾蚴腹吸盘细胞内,但也可自肺期童虫和成虫检出。实验发现,尾蚴分泌的和童虫膜内的28kDa蛋白酶将C3,C3b,iC3b及C9裂解,裂解的iC3b分子沉积于体表,达到童虫保护自身的目的,因而限制了利用补体受体,特别是CR3。用蛋白酶抑制剂处理后可加强补体及嗜中性细胞对血吸虫的 The interaction of Schistosoma mansoni with its host immune system is influenced by a number of specific and nonspecific evasion mechanisms, but little is known about the molecular level of this mechanism. The authors believe that the four proteins are related to this mechanism. The first M28, a membrane-spanning serine protease with a molecular weight of 28 kDa, cleaves the complement protein and is present in the cells of the cercaria abdominal pleat, but can also be detected from the parasites and adults of the lung. The experiment found that cercariae and schistosomula membrane 28kDa protease will C3, C3b, iC3b and C9 cleavage, lytic iC3b molecules deposited in the body surface, to achieve the purpose of squirrels to protect themselves, thus limiting the use of complement receptors, especially Is CR3. Treatment with protease inhibitors potentiates complement and neutrophil responses to schistosomes