目的探寻新型可显影终末型永久性血管栓塞剂。方法采用自行研制的聚N取代丙烯酰胺凝胶作为栓塞剂对10只犬行肾动脉栓塞术,观察使用状况和栓塞效果。结果10只犬肾动脉栓塞术均获成功。病理检查:栓塞2d肾脏呈急性栓塞性梗死,7～10d肾脏呈弥漫性梗死,1～3个月肾脏显著萎缩,广泛纤维化及瘢痕形成。新型栓塞剂流动性好,易于推动,并可在X线下清晰显影。结论聚N取代丙烯酰胺凝胶是一种可显影、易于观察栓塞效果及返流情况、栓塞效果确切的终末型永久性栓塞剂。 Objective To explore a new type of terminal permanent endovascular embolization agent. Methods Poly-N-substituted acrylamide gel was used as an embolizing agent in 10 dogs. Renal artery embolization was performed to observe the use status and embolization effect. Results Renal artery embolization of 10 dogs were successful. Pathological examination: 2d renal embolism showed acute embolic infarction, 7 ~ 10d kidney showed diffuse infarction, 1 to 3 months significantly shrinkage of the kidneys, extensive fibrosis and scar formation. New embolic agent fluidity, easy to promote, and can be clearly under X-ray imaging. Conclusion Poly-N-substituted acrylamide gel is a terminal permanent embolic agent that can be developed and easily observed embolization effect and regurgitation, embolization effect.