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目的探讨宫颈上皮内瘤变(cervical intraepithelial neoplasia)及宫颈癌(cervical cancer)与人乳头瘤病毒(human papillomavirus,HPV)感染的相关性。方法分析2007年6月至2009年5月于本院就诊的宫颈病变患者390例为研究对象,所选病例行阴道镜下活检前均采用杂交捕获Ⅱ代(hybrid captureII,HC2)方法,定量检测宫颈HPV DNA的含量。结果①高危型HPV DNA在宫颈正常组中的检出率为31.83%,在CIN组中的检出率为68.06%,在宫颈癌组中的检出率为95.89%,三组间比较有高度统计学意义。②高危型HPV DNA检出率在CINI组为46.96%,CINⅡ组为58.16%,CINⅢ组为96.02%,三组间比较有高度统计学意义。结论宫颈病变的严重程度和HPV DNA检出率呈正相关,HPV DNA检出率越高,宫颈病变的程度越严重。
Objective To investigate the relationship between cervical intraepithelial neoplasia and cervical cancer and human papillomavirus (HPV) infection. Methods 390 cases of cervical lesions treated in our hospital from June 2007 to May 2009 were selected as research objects. Before colposcopy biopsy, hybrid capture II (HC2) Cervical HPV DNA content. Results ① The detection rate of high-risk HPV DNA in cervical normal group was 31.83%, in CIN group was 68.06%, in cervical cancer group, the detection rate was 95.89% Statistical significance. ② The detection rate of high-risk HPV DNA was 46.96% in CINI group, 58.16% in CINⅡ group and 96.02% in CINⅢ group. There was a statistically significant difference among the three groups. Conclusion The severity of cervical lesions is positively correlated with the detection rate of HPV DNA. The higher the detection rate of HPV DNA, the more serious the cervical lesions.