麻醉动物的研究证实了离体组织的发现,即PGF_2α增加支气管阻力,而 PGE_1则拮抗由组胺或刺激述走神经所引起的支气管阻力增加,有时也能减少静止时张力。实验动物结果表明,PGE_1气雾剂不引起心动过速,其作用亦不被心得安所对抗。静脉注射和气雾剂给药在作用上的不同可能是由于注射给药的 PG 在肺中迅速失活所致。在血液中 PGE、F 和 A 均稳定,但循环中的半衰期很短,因 PGF2α, Studies in anesthetized animals confirmed the finding of isolated tissues that PGF 2α increased bronchial resistance, whereas PGE 1 antagonized the increase in bronchial resistance caused by histamine or nerve stimulation, and sometimes reduced resting at rest. Experimental animal results show that, PGE_1 aerosol does not cause tachycardia, its role is not feel safe from confrontation. The difference in effect between intravenous and aerosol administration may be due to the rapid inactivation of PG administered by injection in the lungs. PGE in the blood, F and A are stable, but the cycle of half-life is very short, due to PGF2α,