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近年来发现,M受体数目可以发生变化,激动剂使之减少,而阻滞剂使之增多。胆碱能神经系统功能,可能通过改变M受体的数量而得到调节。和肾上腺素能受体等相似,M受体也可能存在亚型分类,其功能也有所不同。胆城能系统和其它神经系统存在相互联系相互制约的关系。例如胆碱能神经元存在抑制性DA受体,而DA能神经元的活动也可受到胆碱能抑制性调控。胆碱能神经未梢存在α受体,肾上腺素能也存在M受体,这些受体激活则抑制相应的神经未梢递质的释放。胆碱能神经末梢支配GABA能神经元,而胆碱能神经元也存在抑制性GABA受体。5—HT可使纹状体Ach释放减少,而M受体激动剂使脑中5—HT转换率增加。
In recent years, it has been found that the number of M receptors can be changed, the agonist decreases, and the blockers make it more. Cholinergic nervous system function may be regulated by changing the number of M receptors. And adrenergic receptors and other similar, M receptors may also exist subtype, its function is also different. Biliary system and other nervous systems exist interconnected and mutually restrictive relationship. For example, cholinergic neurons have inhibitory DA receptors, while DA neurons can also be cholinergicly regulated. Cholinergic nerve tips present α receptors, adrenergic receptors also exist M, these receptor inhibit the release of the corresponding neurotransmitter neurotransmitters. Cholinergic nerve endings dominate GABAergic neurons, whereas cholinergic neurons also have inhibitory GABA receptors. 5-HT reduced striatal Ach release, whereas M receptor agonists increased 5-HT turnover in the brain.