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本试验由多中心参加,按照双盲、安慰剂对照和交叉的方式进行。研究静脉注射单剂索他洛尔(1.5mg/kg,在10分钟内)终止持续时间≥15分钟的阵发性室上速的有效率和安全性。恢复正常窦性心律为有效,反之无效。患者随机分组,首先分别给予索他洛尔和安慰剂。如果在20分钟内无效,交叉改用另一药物。 43例阵发性室上速患者中,5例分别误诊为房扑,给药前恢复窦性心律,误将输液管插入皮下,发生低血压,出现宽QRS波心动过速。其余38例供有效率分析,包括15例自发性室上速,23例诱发的室上速。依室上速机制划分,27例房室绪折返性室上速,11例经旁道逆传的环行室上速(这11例均属诱
This trial is multicenter and conducted in a double-blind, placebo-controlled and crossover manner. The efficacy and safety of a single dose of sotalol (1.5 mg / kg within 10 minutes) of paroxysmal supraventricular tachycardia with a duration of> 15 minutes was studied. Return to normal sinus rhythm is effective, otherwise ineffective. Patients were randomly assigned to receive sotalol and placebo first. If not effective within 20 minutes, switch to another medication. Of the 43 patients with paroxysmal supraventricular tachycardia, 5 were misdiagnosed as atrial flutter, sinus rhythm was restored before administration, mistakenly inserted into the subcutaneous infusion tube, hypotension, wide QRS tachycardia occurred. The remaining 38 patients were analyzed for efficacy, including 15 cases of spontaneous supraventricular tachycardia and 23 cases of supraventricular tachycardia. According to the mechanism of supraventricular tachycardia, 27 cases of atrioventricular rexovarxal superficial velocity and 11 cases of retrograde retrograde supraventricular tachycardia (these 11 cases are induced