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目的:观察马甲子叶不同提取部位的抗炎作用,并筛选其有效部位。方法:系统溶剂法将马甲子叶提取为氯仿、乙酸乙酯、正丁醇和水4个部位后,用耳肿胀法、足跖肿胀法、实验性腹膜炎法筛选马甲子叶的抗炎有效部位,并考察其作用机理。结果:马甲子叶正丁醇、水及乙酸乙酯部位为抗炎的有效部位。其中以正丁醇部位作用最佳,其对角叉菜胶液致胸膜炎大鼠胸腔渗出液及肺组织中MDA、PGE2、TNF-α及IL-1β的含量升高有显著的抑制作用(P<0.01)。结论:正丁醇和水部位是马甲子叶的有效抗炎部位,以正丁醇部位作用最佳,具有抑制炎症介质释放及抗脂质过氧化的作用。
OBJECTIVE: To observe the anti-inflammatory effects of different extract parts of vera cotyledons and to screen the effective parts. Methods: The systemic solvent method was used to extract the cotyledons of the caraway from the four parts of chloroform, ethyl acetate, n-butanol and water. The anti-inflammatory active fractions of the carambola cotyledon were screened by ear swelling method, paw edema method and experimental peritonitis method. Its mechanism of action. Results: Butanol, water and ethyl acetate of cotyledons were effective anti-inflammatory sites. Among them, n-butanol had the best effect, which significantly inhibited the increase of MDA, PGE2, TNF-α and IL-1β in pleural effusion and lung tissue of rats with pleurisy induced by carrageenan P <0.01). CONCLUSION: n-butanol and water are potent anti-inflammatory sites of cotyledon cotyledons, and n-butanol is the most effective anti-inflammatory agent with the effect of inhibiting the release of inflammatory mediators and anti-lipid peroxidation.