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自从1952年 Charpentier 合成氯丙嗪并用于精神病,至今已近30年,在这期间,尤其随着细胞生物学的迅速进展,神经递质微量测定和受体分离工作获得成功,加之电生理、微电泳、荧光组织化学、电镜超微结构观察等新技术的广泛使用,促进了对精神病本质的认识,使精神药物在合成、药理作用原理的研究等方面有了很大的进展,本文通过复习有关文献,围绕精神药物的分类、临床应用、副作用及注意事项、作用机制作一综述。
Since 1952, Chlorphenamine was synthesized by Charpentier and used for mental illness, which has been nearly 30 years. During this period, especially with the rapid progress of cell biology, the success of neurotransmitter determination and receptor separation was achieved. In addition, electrophysiological and micro Electrophoresis, fluorescence histochemistry, ultrastructure observation of electron microscopy and other new technologies are widely used to promote the understanding of the nature of psychosis, the psychotropic drugs in the synthesis, the pharmacological effects of the principle of research has made great progress, this article review Literature, focusing on the classification of psychotropic substances, clinical applications, side effects and precautions, mechanism of action is reviewed.