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目的了解婴儿麻疹母传抗体相关因素及抗体消长情况,为小月龄婴儿麻疹疫苗免疫策略制定提供依据。方法采集新生儿0、3、6、8月龄血清标本共计346份,使用ELLSA方法进行麻疹Ig G抗体水平检测。结果无锡市城镇和农村两个地区的新生儿麻疹母传抗体总的水平为380.09 m IU/ml,低于国内研究结果;3月龄起麻疹母传抗体水平逐年下降(χ2=143.30,P<0.001),农村婴儿抗体水平高于城镇婴儿(F=16.796,P<0.001)。结论自3月龄起母传抗体保护作用消失,成为麻疹易感儿,应考虑提前接种麻疹疫苗或育龄妇女加强免疫麻疹成分疫苗,控制小月龄麻疹发病。
Objective To understand the related factors of maternal measles antibody and the growth and elimination of antibody in infancy and provide evidence for the immunization strategy of measles vaccine for infants with small age. Methods A total of 346 serum samples were collected from 0, 3, 6, and 8 months old neonates. IgE antibody levels of measles were detected by ELLSA. Results The total level of newborn measles antibody was 380.09 m IU / ml in both urban and rural areas in Wuxi City, which was lower than the domestic research results. The level of measles-transmitted maternal antibody decreased year by year (χ2 = 143.30, P < 0.001). The level of infant antibody in rural areas was higher than that of urban infants (F = 16.796, P <0.001). CONCLUSION: The protective effect of mother-antibody disappeared from 3 months of age and became a measles-susceptible child. Therefore, measles vaccine or women of childbearing age should be considered to strengthen the immunization against measles vaccine and to control the incidence of measles.