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Angew.Chem.Int.Ed.2016,55,2147~2151通过催化剂控制反应的化学或非对映选择性是不对称催化的研究热点,能够以相同的原料在相似的反应条件下生成不同产物,从而提高合成效率;而在反应中能够同时实现化学和非对映选择性的调控、构建多样性手性化合物是一项极具挑战性的工作.四川大学华西药学院陈应春课题组使用不同手性Lewis碱,在催化靛红衍生的MoritaBaylis-Hillman碳酸酯和2-亚烷基-1,3-茚二酮的环化反应中成功地实现了化学选择性和非对映选择性的调控.手性
Angew.Chem.Int.Ed.2016,55,2147 ~ 2151 Chemical or diastereoselective control of a reaction by a catalyst is a hot research topic for asymmetric catalysis and enables the production of different products under similar reaction conditions using the same starting materials, Thereby increasing the efficiency of synthesis; and in the reaction can be simultaneously chemical and diastereoselective regulation, the construction of a variety of chiral compounds is a very challenging work .Chengxi University, West China College of Medicine Chen Yingchun task force using different chiral Lewis base, successfully achieved chemoselectivity and diastereoselectivity in the cyclization of catalysis of isatin-derived Morita Baylis-Hillman carbonate and 2-alkylidene-1,3-indandione. Sex