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目的探讨神经梅毒的诊断及脑脊液检查在神经梅毒诊断中的重要性。方法回顾性分析14例梅毒患者临床特点及脑脊液检查结果。结果确诊神经梅毒7例,疑似神经梅毒3例,排除神经梅毒4例。脑脊液检查RPR阳性7例,TPHA阳性13例。脑脊液白细胞计数增高8例,蛋白质测定增高10例。结论神经梅毒诊断无金标准,均需根据临床表现、血清学试验、脑脊液检查及放射学扫描综合判断。部分病例诊断困难。脑脊液检查在神经梅毒诊断中具有不可缺失的重要地位。
Objective To investigate the diagnosis of neurosyphilis and the importance of cerebrospinal fluid in the diagnosis of neurosyphilis. Methods Retrospective analysis of 14 cases of syphilis clinical characteristics and cerebrospinal fluid test results. Results 7 cases of neurosyphilis were diagnosed, 3 cases of suspected neurosyphilis were diagnosed and 4 cases of neurosyphilis were excluded. CSF RPR positive in 7 cases, TPHA-positive in 13 cases. Cerebrospinal fluid leukocyte count increased in 8 cases, increased protein 10 cases. Conclusion The diagnosis of neurosyphilis without gold standard, based on clinical manifestations, serological tests, cerebrospinal fluid examination and radiological scanning comprehensive judgment. In some cases the diagnosis is difficult. Cerebrospinal fluid in the diagnosis of neurosyphilis has an indispensable important position.