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慢性腹泻是婴幼儿常见疾病,严重影响婴幼儿体格与智力发育。肠黏膜损伤的持续存在和修复延迟,是慢性腹泻病程迁延不愈的重要因素。因此,促进肠黏膜的修复,对慢性腹泻患儿的治疗意义重大。近年来发现谷氨酰胺(Glutamine,Gln)是肠道的特殊营养素,在维持肠道结构和功能的完整上起重要作用。多种实验动物模型的研究发现,给予外源性Gln能够防止小肠黏膜萎缩,促进黏膜细胞的分裂增殖。但补充Gln是否有助于慢性腹泻患儿肠黏膜的修复,目前尚未见报道。本研究拟建立慢性腹泻幼鼠模型,探讨Gln对慢性腹泻幼鼠肠黏膜修复的影响。
Chronic diarrhea is a common disease in infants and young children, seriously affecting the physical and mental development of infants and young children. The continuous existence of intestinal mucosal injury and repair delay, is an important factor in the delayed course of chronic diarrhea. Therefore, to promote the repair of intestinal mucosa, the treatment of children with chronic diarrhea is of great significance. In recent years, glutamine (Glutamine, Gln) is found to be a special nutrient in the intestine and plays an important role in maintaining the integrity of intestinal structure and function. A variety of experimental animal models found that exogenous Gln administration can prevent mucosal atrophy and promote mucosal cell division and proliferation. However, whether Gln supplementation in children with chronic diarrhea intestinal mucosa repair, has not been reported. This study intends to establish a model of chronic diarrhea in young rats to investigate the effect of Gln on intestinal mucosal repair in rats with chronic diarrhea.