流行性出血热(Epidemic HemorrhagicFever,EHF)是由汉坦病毒(HantaanVirus,HV)引起的以发热、出血和肾脏损害为主要临床表现的急性传染病。多年来国内外学者一直致力干EHF发病机理的研究,曾先后提出过病毒直接作用学说、丘脑下部间脑炎学说、弥漫性血管内凝血学说及神经体液因素学说。随着临床免疫学的发展,又开始了对本病免疫发病机理的探讨。现已有相当多的证据表明,本病是以病毒感染为始动因素,以免疫反应为主要环节的疾 Epidemic Hemorrhagic Fat (EHF) is an acute infectious disease caused by Hantaan Virus (HV), which is the main clinical manifestation of fever, hemorrhage and renal damage. Over the years, domestic and foreign scholars have been devoting themselves to the research on the pathogenesis of EHF. They have successively put forward the theory of virus direct action, hypothalamic encephalitis theory, diffuse intravascular coagulation theory and neurohumoral fluid theory. With the development of clinical immunology, and began to explore the pathogenesis of immune disease. Now there is considerable evidence that the disease is a viral infection as a starting factor to the immune response as the main part of the disease