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目的探讨在进展期胃癌治疗中应用新辅助化疗方案对患者生活质量的影响。方法收集进展期胃癌且接受手术治疗72例患者资料,根据其化疗方案分为未化疗组(A组,26例)、新辅助化疗组(B组,24例)和传统化疗组(C组,22例),对比分析3组患者的术后生活质量。结果 A和B组的GQL评分以及QLO-C30评分均显著优于C组,差异有统计学意义(P<0.05),B组认知功能评分显著高于对照组,疲劳、疼痛、呼吸困难、腹泻及GQL评分均显著高于A组,差异有统计学意义(P<0.05)。A组患者的复发率为11.5%,B和C组患者近期无复发,A组与B和C组比较差异,有统计学意义(P<0.05)。结论进展期胃癌患者手术治疗患者中,应用新辅助化疗方案有利于改善治疗效果和患者的生活质量,值得推广应用。
Objective To explore the effect of neoadjuvant chemotherapy on quality of life in patients with advanced gastric cancer. Methods The data of 72 patients with advanced gastric cancer were collected and undergone surgical treatment. According to the chemotherapy regimen, they were divided into three groups: untreated group (A group, 26 cases), neoadjuvant chemotherapy group (B group, 24 cases) and conventional chemotherapy group (C group, 22 cases), comparative analysis of three groups of postoperative quality of life. Results The scores of GQL and QLO-C30 in group A and group B were significantly better than those in group C (P <0.05). The score of cognitive function in group B was significantly higher than that in control group. The fatigue, pain, dyspnea, Diarrhea and GQL scores were significantly higher than those in group A (P <0.05). The recurrence rate in group A was 11.5%. There was no recent recurrence in group B and C, and the difference between group A and B and C was statistically significant (P <0.05). Conclusion In patients with advanced gastric cancer surgery, the application of neoadjuvant chemotherapy is beneficial to improve the therapeutic effect and quality of life of patients, which is worth popularizing and applying.