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[目的]探讨氰戊菊酯对小鼠组织中ATP酶活性的影响。[方法]将小鼠随机分为高剂量组(染毒剂量27.2mg/kg)、中剂量组(染毒剂量13.6mg/kg)、低剂量组(染毒剂量6.8mg/kg)和1个对照组,染毒后测定组织中ATP酶活性。[结果]染毒后,高、中、低染毒组和对照组肝组织中Na+-K+-ATP酶活性分别为16.879±4.587、18.659±3.314、21.174±4.006、24.175±3.832μmol·L-1·mgpro-1·h-1;肾组织中各组活性分别为9.275±3.580、12.012±2.640、13.093±1.883、15.034±3.383μmol·L-1·mgpro-1·h-1;脑组织中各组活性分别为15.490±3.399、18.208±3.127、19.825±2.520、21.065±2.658μmol·L-1·mgpro-1·h-1;高、中、低染毒组和对照组肝组织中Ca2+-Mg2+-ATP酶活性分别为15.371±3.386、18.297±3.654、20.307±3.835、22.146±3.746μmol·L-1·mgpro-1·h-1;肾组织中各组活性分别为7.753±2.025、11.711±2.396、15.284±3.812、17.047±4.042μmol·L-1·mgpro-1·h-1;脑组织中各组活性分别为13.835±3.415、16.895±2.778、18.446±2.243、20.027±3.380μmol·L-1·mgpro-1·h-1。与对照组相比,各染毒组Na+-K+-ATP酶和Ca2+-Mg2+-ATP酶活性有降低的趋势。肝、脑、肾的高剂量组和中剂量组的Na+-K+-ATP和Ca2+-Mg2+-ATP酶均低于对照组,差异有统计学意义(P﹤0.05)。[结论]氰戊菊酯对ATP酶有抑制作用,可能对机体组织和细胞有损害作用。
[Objective] To investigate the effect of fenvalerate on ATPase activity in mice. [Methods] The mice were randomly divided into high dose group (27.2mg / kg), medium dose (13.6mg / kg), low dose (6.8mg / kg) and 1 In the control group, the activity of ATPase in the tissue was determined after exposure to the virus. [Results] The activities of Na + -K + -ATP in liver tissue of high, medium and low toxicity groups were 16.879 ± 4.587, 18.659 ± 3.314, 21.174 ± 4.006, 24.175 ± 3.832μmol·L-1, · Mgpro-1 · h-1. The activity of each group in renal tissue was 9.275 ± 3.580,12.012 ± 2.640,13.093 ± 1.883,15.034 ± 3.383μmol·L-1 · mgpro-1 · h-1, Group activity was 15.490 ± 3.399, 18.208 ± 3.127, 19.825 ± 2.520, 21.065 ± 2.658μmol·L-1 · mgpro-1 · h-1 respectively. The levels of Ca2 + -Mg2 + -ATPase activity were 15.371 ± 3.386, 18.297 ± 3.654, 20.307 ± 3.835, 22.146 ± 3.746μmol·L-1 · mgpro-1 · h-1 respectively. The activity of each group in renal tissue was 7.753 ± 2.025, 11.711 ± 2.396 , 15.284 ± 3.812,17.047 ± 4.042μmol·L-1 · mgpro-1 · h-1 respectively. The activity of each group in brain tissue was 13.835 ± 3.415,16.895 ± 2.778,18.446 ± 2.243,20.027 ± 3.380μmol·L-1 · Mgpro-1 · h-1. Compared with the control group, the activity of Na + -K + -ATPase and Ca2 + -Mg2 + -ATPase in each treatment group tended to decrease. The levels of Na + -K + -ATP and Ca2 + -Mg2 + -ATPase in liver, brain and kidney were lower than those in control group (P <0.05). [Conclusion] Fenvalerate can inhibit the ATPase and may damage the tissues and cells.