在室温的条件下,建立了一种简单实用的铜催化制备含酮羰基或酯基的喹唑啉-4(3H)-亚基类衍生物的新方法.实验证明以2-溴苯甲酰乙酸甲酯类似物及脒盐酸盐为原料,碘化亚铜为催化剂,磷酸钾为碱,无添加配体的情况下,可成功制备一系列喹唑啉类衍生物.其结构均经1H NMR、13C NMR及HRMS确证. A simple and practical copper-catalyzed method for the preparation of quinazoline-4 (3H) -subunit derivatives containing keto carbonyl groups or ester groups was established at room temperature.It was proved that 2-bromobenzoyl Methyl acetate analogue and amidine hydrochloride as raw materials, cuprous iodide as catalyst and potassium phosphate as base, a series of quinazoline derivatives can be successfully prepared without adding ligands.The structures were all confirmed by 1H NMR, 13C NMR and HRMS.