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目的观察分析112例慢性牙周炎患者应用中药骨碎补联合多西环素治疗的效果。方法从医院门诊就诊的患者中选取224例慢性牙周炎患者,随机分为观察组与对照组,每组112例。观察组给予中药骨碎补联合多西环素治疗,对照组给予甲硝唑液治疗,观察比较2组治疗前后牙龈出血指数(SBI)、患牙附着丧失(AL)、牙齿松动度(TM)、菌斑指数(PLI)以及ALP相关酶的活性。结果 2组患者治疗后病情均有好转,观察组TM、SBI、AL及PLI数改善更大,且ALP活性比对照组低,而SOD、GPx活性显著高于对照组,2组比较差异均具有统计学意义(P<0.01)。结论中药骨碎补联合多西环素治疗慢性牙周炎效果更佳,值得临床推广应用。
Objective To observe and analyze 112 cases of chronic periodontitis patients treated with traditional Chinese medicine combined with ganaduodundan. Methods Totally 224 patients with chronic periodontitis were selected from the outpatients in the hospital and randomly divided into observation group and control group with 112 cases in each group. The observation group was treated with traditional Chinese medicine Rhizoma Drynariae combined with doxycycline and the control group with metronidazole solution. The SBI, AL and TM were compared between the two groups before and after treatment. , Plaque index (PLI) and ALP-related enzyme activity. Results After treatment, the patients in both groups improved their symptoms. The scores of TM, SBI, AL and PLI in the observation group were significantly improved, and the activities of ALP were lower than those in the control group, while the activities of SOD and GPx were significantly higher than those in the control group Statistical significance (P <0.01). Conclusion Traditional Chinese medicine Drynaria combined with doxycycline in the treatment of chronic periodontitis is better and worthy of clinical application.