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作者以往的研究表明,丹参具有活血化瘀作用,并从丹参水提取物中分离出紫草酸镁B,曾对其结构和活性进行了报道。本次就紫草酸镁B对肾功能各项指标的影响进行了观察。 实验方法:以雄性Wistar大鼠作为实验动物.按作者以往报道的方法提取紫草酸镁B,用丙三醇肌注制作急性肾小管坏死大鼠肾衰模型。二种实验设计为:①大鼠每天口服紫草酸镁B 20mg/kg,共20天。断水18h后
The author’s previous studies have shown that Salvia miltiorrhiza has a role in promoting blood circulation and removing magnesium lithospermate B from the aqueous extract of Salvia miltiorrhiza, and its structure and activity have been reported. The effect of magnesium lithospermate B on various indicators of renal function was observed. Experimental method: male Wistar rats were used as experimental animals. Magnesium oxalate B was extracted according to the author’s previous reports. The renal failure model of acute tubular necrosis was established by intramuscular injection of glycerol. Two kinds of experiments were designed as follows: 1 Rats were treated daily with oral magnesium oxalate B 20 mg/kg for 20 days. After water cut 18h