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对25例原发性肾病综合征（PNS）病儿激素治疗前后应用高压液相技术测定25-（OH）D3，光电子吸收法测定骨粒密度（包括线密度BMCg／cm，面密度BMDg／cm2）。与正常比较，PNS治疗前的BMC、BMD及VitD3均显著下降，P＜005。提示PNS有明显的骨代谢障碍，激素治疗对患儿VitD3的代谢及骨化作用也有影响。
The 25- (OH) D3 was measured by high pressure liquid phase before and after steroid treatment in 25 children with primary nephrotic syndrome (PNS). The bone density (including linear density BMCg / cm, areal density BMDg / cm2 ). Compared with the normal, PNS before treatment, BMC, BMD and VitD3 were significantly decreased, P <005. Prompt PNS obvious bone metabolism disorders, hormone therapy VitD3 in children with the role of metabolism and ossification.