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目的:应用应变率成像技术(SRI)动态观察和评价吗啡预处理对兔心肌缺血再灌注损伤时左室长轴功能的影响。方法:建立新西兰大白兔心肌缺血再灌注模型,随机分为假手术组(SH组)、吗啡预处理组(MF组)和生理盐水预处理组(NS组)。于手术前1天及手术术后28天内不同时间点测量超声心动图常规数据及左室各壁收缩期峰值速度与应变率参数。结果:术后1天,MF组与NS组左室整体与局部心肌收缩功能较术前和SH组明显减低(P<0.05),并随缺血再灌注时间的延长呈减低趋势(P<0.05),且NS组减低更明显(P<0.05)。结论:SRI技术能够客观、准确地评价缺血再灌注损伤心肌的局部收缩功能的变化,而吗啡预处理对兔心肌缺血再灌注损伤存在明显的弱化作用。
Objective: To observe and evaluate the effect of morphine preconditioning on left ventricular long axis function in myocardial ischemia-reperfusion injury in rabbits by using strain rate imaging (SRI) technique. Methods: New Zealand white rabbits model of myocardial ischemia reperfusion was established and randomly divided into sham operation group (SH group), morphine preconditioning group (MF group) and saline preconditioning group (NS group). Conventional echocardiographic data and peak systolic velocity and strain rate parameters were measured at 1 day before surgery and at 28 days after surgery. Results: At 1 day after operation, left ventricular total and regional myocardial contractile function in MF group and NS group were significantly lower than those in preoperative and postoperative SH (P <0.05), and decreased with the duration of ischemia / reperfusion (P <0.05 ), And the NS group decreased more significantly (P <0.05). CONCLUSIONS: SRI can objectively and accurately evaluate the changes of local systolic function in myocardial ischemia-reperfusion injury, while morphine preconditioning can significantly attenuate myocardial ischemia-reperfusion injury in rabbits.