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In the study of quantitative structure-activity relationships (QSARs), Hansch’s linear free-energy relationships (LFERs) are the most commonly used. However, LFERs have many limitations. Free-Wilson method has its specialties in the study of QSARs. It is es pecially suitable for the compounds of the same parent structure and with this method, the physicochemical parameters of the compounds are not necessarily calculated. The method can give the contribution of each substitute on each position. Though free-Wilson method
In the study of quantitative structure-activity relationships (QSARs), Hansch’s linear free-energy relationships (LFERs) are the most commonly used. However, LFERs have many limitations. Free-Wilson method has its specialties in the study of QSARs. It is es pecially suitable for the compounds of the same parent structure and with this method, the physicochemical parameters of the compounds are not determined calculated. The method can give the contribution of each substitute on each position.