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目的 回顾性探讨PET/MR在全身性肿瘤筛查、局部肿瘤显像及神经系统功能成像中的临床价值.方法 共入组志愿者425例[男149例,女276例,年龄21～82(平均56)岁],其中全身性肿瘤筛查58例,局部肿瘤显像264例,神经系统功能成像103例,均行全身或局部18F-FDG PET/MR检查.结果 58例PET/MR全身性肿瘤筛查结果阳性49例(84.48％),均为良性病变;局部肿瘤显像中,病灶阳性显示率(含34例18 F-FDG PET阴性肿瘤患者)为100％ (264/264),诊断准确性为95.45％(252/264),其中56例宫颈癌PET/MR的国际妇产科联盟(FIGO)分期诊断准确性为92.86％(52/56),46例鼻咽癌患者近期疗效评价CR率为69.57％ (32/46);103例神经系统功能成像中,92例(89.32％) PET/MR阳性诊断经手术及临床随访证实为真阳性.结论 PET/MR一站式检查可显著提高疾病的显示及诊断的准确性,可为临床提供有价值的病变定位、定性、定量及功能信息.“,”Objective To retrospectively evaluate the clinical application of hybrid PET/MR in whole-body tumor screening,regional tumor imaging and central nervous system (CNS) functional imaging.Methods A total of 425 volunteers (149 males,276 females,age:21-82 (mean 56) years) were enrolled in this study,including 58 healthy subjects for whole-body PET/MR,264 cases with tumors for regional PET/MR and 103 cases with CNS problems for CNS PET/MR.Results A total of 49 cases (84.48％) undergoing whole-body PET/MR had positive results which were all proved to represent benign lesions.Regional PET/MR was positive in 100％ of patients (264/264,34 cases were 18F-FDG PET negative),and the diagnostic accuracy was 95.45％ (252/264).The accuracy for PET/MR staging in cervical carcinomas was 92.86％ (52/56) and CR ratio of nasopharyngeal carcinomas was 69.57％ (32/46).CNS PET/MR was positive in 92 cases (89.32％) which were confirmed true positive by post-operative pathology and clinical follow-up.Conclusions PET/MR might improve lesion detection rate and diagnostic accuracy.It could provide accurate lesion localization,qualification,quantification and function assessment.