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本研究应用PCR技术检测201例单纯性肥胖儿童青少年和230例正常体重儿童青少年解偶联蛋白2基因第8号外显子的插入/缺失多态性,结果显示该多态性类型为45bp串联重复序列之一的插入或缺失,此多态性与儿童青少年单纯性肥胖无显著关联。
In this study, PCR was used to detect the insertion / deletion polymorphisms of exon 8 of uncoupling protein 2 gene in 201 adolescents with obesity and 230 normal weight children. The results showed that the polymorphism was 45bp tandem repeat Insertion or deletion of one of the sequences showed no significant association with simple obesity in children and adolescents.