论文部分内容阅读
为探讨内皮素－１（ＥＴ－１）及一氧化氮（ＮＯ）在过敏性哮喘发病机制中的作用及心钠素（ＡＮＦ）对哮喘转归的意义，检测了哮喘豚鼠血浆及支气管肺泡灌洗液（ＢＡＬＦ）中ＥＴ－１、ＡＮＦ、ＮＯ２－／ＮＯ３－、ｃＧＭＰ含量。结果显示，哮喘组ＥＴ－１、ＡＮＦ、ｃＧＭＰ含量均显著高于对照组；哮喘组ＢＡＬＦ中的ＮＯ２－／ＮＯ３－含量高于对照组；ＥＴ－１与ＮＯ２－／ＮＯ３－含量变化呈中度负相关；ＥＴ－１与ＡＮＦ含量变化呈显著负相关；ＮＯ２－／ＮＯ３－和ＡＮＦ含量与ｃＧＭＰ含量变化呈显著正相关。表明ＥＴ－１与ＮＯ在哮喘发病中起重要作用，ＡＮＦ负反馈抑制ＥＴ－１的合成与释放
To investigate the role of endothelin-1 (ET-1) and nitric oxide (NO) in the pathogenesis of allergic asthma and the significance of atrial natriuretic peptide (ANF) in asthma, the plasma and bronchoalveolar lavage ET-1, ANF, NO2- / NO3-, cGMP content in the lotion (BALF). The results showed that the levels of ET-1, ANF and cGMP in asthma group were significantly higher than those in the control group; the content of NO2- / NO3- in BALF in asthma group was higher than that in the control group; the content of ET-1 and NO2- / Negative correlation between ET-1 and ANF content; NO2- / NO3- and ANF content had a significant positive correlation with cGMP content. ET-1 and NO play an important role in the pathogenesis of asthma. ANF negative feedback inhibits the synthesis and release of ET-1