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氯雷他定片为北京某研究所研制的四类新药,为长效、无镇静作用的第三代三环类抗组胺药物。用于过敏性鼻炎、急慢性荨麻疹及其他过敏性疾病的治疗。本文建立了反相HPLC法,采用紫外检测器测定氯雷他定及其片剂的含量。 1 仪器与试药 美国惠普HP1100型高效液相色谱仪(包括HP1100型泵,可变波长紫外检测器和LC3DHP工作站)。氯雷他定原料、氯雷他定对照品、氯雷他定片及氯雷他定前体均由北京某
Loratadine tablets for the Beijing Institute of one of four new drugs developed for the long-acting, non-sedating third-generation tricyclic antihistamines. For allergic rhinitis, acute and chronic urticaria and other allergic diseases. In this paper, a reversed-phase HPLC method was established, and the content of loratadine and its tablets was determined by ultraviolet detector. 1 instruments and reagents HP Hewlett-Packard HP1100 HPLC (including HP1100 pump, variable wavelength UV detector and LC3DHP workstations). Loratadine raw materials, loratadine reference substance, loratadine tablets and loratadine precursors by a Beijing