Achen等初步研究了胃食管返流在经测压确定为“胡桃夹食管”患者的胸痛中所起的作用。结果提示“胡桃夹”患者大多数患有返流性疾病,奥美拉唑及大剂量雷尼替丁可使83％的受试患者胸痛减轻,但常常并不能改变患者的“胡桃夹”状态,提示对非心源性胸痛患者在考虑“胡桃夹食管”这一诊断而作抗痉挛治疗前要先排除胃食管返流。 Achen and other preliminary study of the role of gastroesophageal reflux in chest pain in patients with pressure test determined as “nutcracker esophagus.” The results suggest that most patients with Nutcracker suffer from reflux disease. Omeprazole and high-dose ranitidine relieved chest pain in 83% of patients, but often did not change the patient’s “Nutcracker” status , Suggesting that patients with non-cardiac chest pain in the consideration of “nutcracker esophagus,” the diagnosis of antispasmodic treatment should be ruled out before gastroesophageal reflux.