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对历史悠久的临床试验重新进行严格的科学评价,我们将有何反应?90年前被首次描述的皮肤出血时间提供了临床评价血小板和小血管止血作用的方法。该方法被用于检测血管性假血友病和某些血小板功能性疾病,并作为某些疾病在手术或活检时严重出血的预示参数。我们知道,试验结果受血细胞压积、尿毒症和许多药物(特别是阿司匹林)的影响,也可能受高血压和高血清胆红素的影响。
What will we respond to by re-performing rigorous scientific reviews of historic clinical trials? The skin bleeding time, first described 90 years ago, provides a clinically useful method of assessing the effects of hemostasis on platelets and small blood vessels. This method is used to detect von Willebrand’s disease and certain platelet functional disorders and serves as a predictor of severe bleeding of certain diseases during surgery or biopsy. We know that the test results are affected by hematocrit, uremia and many medications (especially aspirin) and may also be affected by high blood pressure and high serum bilirubin.