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目的探讨丁苯酞氯化钠注射液联合脑心通胶囊对急性脑卒中患者血清炎性因子水平及生活质量的影响。方法选取2014年1月—2015年8月南京鼓楼医院收治的急性脑卒中患者124例,采用随机数字表法分为观察组与对照组,各62例。两组患者均予以常规治疗,对照组患者予以丁苯酞氯化钠注射液治疗,观察组患者予以丁苯酞氯化钠注射液联合脑心通胶囊治疗;两组患者均连续治疗2周。比较两组患者治疗前后血清炎性因子〔白介素6(IL-6)、白介素8(IL-8)、白介素10(IL-10)、C反应蛋白(CRP)〕水平、临床疗效、治疗后改良Rankin(mRS)评分及日常生活自理能力量表(ADL)评分、治疗前后美国国立卫生研究院卒中量表(NIHSS)评分。结果治疗前两组患者血清IL-6、IL-8、IL-10、CRP水平比较,差异无统计学意义(P>0.05);治疗后观察组患者血清IL-6、IL-8、IL-10、CRP水平低于对照组(P<0.05)。观察组患者临床疗效优于对照组(P<0.05)。观察组患者治疗后mRS评分低于对照组、ADL评分高于对照组(P<0.05)。治疗前两组患者NIHSS评分比较,差异无统计学意义(P>0.05);治疗后观察组患者NIHSS评分低于照组(P<0.05)。结论丁苯酞氯化钠注射液联合脑心通胶囊治疗急性脑卒中的临床疗效确切,可有效降低患者血清炎性因子水平,改善患者的生活质量及神经功能。
Objective To investigate the effect of Butylphthalide and sodium chloride injection combined with Naoxintong capsule on serum inflammatory factors and quality of life in patients with acute stroke. Methods A total of 124 acute stroke patients admitted to Nanjing Drum Tower Hospital from January 2014 to August 2015 were randomly divided into observation group and control group with 62 cases in each group. Patients in both groups were treated with sodium butylphthalide and sodium chloride injection. Butylphthalide and sodium chloride injection combined with Naoxintong capsule were given in both groups. Patients in both groups were treated continuously for 2 weeks. The levels of serum inflammatory cytokines IL-6, IL-8, IL-10 and CRP before and after treatment were compared between the two groups. The clinical efficacy, improvement after treatment Rankin (mRS) score and ADL score were used to assess the NIHSS score before and after treatment. Results There was no significant difference in serum IL-6, IL-8, IL-10 and CRP levels between the two groups before treatment (P> 0.05). After treatment, the levels of IL-6, IL- 10, CRP level was lower than the control group (P <0.05). The clinical efficacy of the observation group was better than that of the control group (P <0.05). The mRS score of the observation group was lower than that of the control group after treatment, and the ADL score was higher than that of the control group (P <0.05). There was no significant difference in NIHSS score between the two groups before treatment (P> 0.05). NIHSS score in the observation group was lower than that in the control group after treatment (P <0.05). Conclusion Butylphthalide sodium chloride injection combined with Naoxintong capsule in the treatment of acute stroke has definite clinical curative effect, which can effectively reduce the level of serum inflammatory cytokines and improve the quality of life and neurological function.