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【目的】比较不同治疗方式对小细胞肺癌(Small cell lung cancer,SCLC)治疗生存率的影响。【方法】回顾分析393例SCLC临床治疗随访资料。其中88例广泛期SCLC采用化疗和/或放疗。局限期SCLC 305例分3组:52例为单纯化/放疗组,123例为化疗+手术+化/放疗组,130例为手术+化/放疗组,对各组1、3、5年生存率进行分析。【结果】局限期SCLC中,单纯化/放疗组1、3、5年生存率为63.4%、28.8%、7.6%,化疗+手术+化/放疗组为82.1%、56.1%、37.4%;手术+化/放疗组为77.7%、44.6%、27.7%。广泛期SCLC 1、2、3、5年存活率为17.0%(15/88)、10.2%(9/88)、0%(0/88)、0%(0/88)。与“单纯化/放疗组”相比,“手术+化/放疗组”和“化疗+手术+化/放疗组”病例的1、3、5年生存率均有提高,差异有显著性(P<0.05);“化疗+手术+化/放疗组”与“手术+化/放疗组”相比,3、5年生存均有提高,差异有显著性(P<0.05)。【结论】广泛期小细胞肺癌已经无手术治疗机会,采用单纯化/放疗保守治疗为主。局限期小细胞肺癌包含手术在内的综合治疗组效果优于单纯化/放疗组,手术前辅助化疗具有有益性和可行性。
【Objective】 To compare the effects of different treatment methods on the survival rate of small cell lung cancer (SCLC). 【Methods】 A retrospective analysis of 393 cases of SCLC clinical follow-up data. Eighty-eight patients with extensive SCLC received chemotherapy and / or radiotherapy. In the SCLC, 305 cases were divided into 3 groups: 52 cases were simple / radiotherapy group, 123 cases were chemotherapy + surgery + radiotherapy / radiotherapy group and 130 cases were operation + chemotherapy / radiotherapy group. Rate analysis. 【Results】 The 1-, 3-, 5-year survival rates of patients in the degenerative SCLC were 63.4%, 28.8% and 7.6%, respectively. The rates of chemotherapy, radiotherapy and radiotherapy were 82.1%, 56.1% and 37.4% + Chemotherapy / radiotherapy group was 77.7%, 44.6%, 27.7%. The survival rates at 1, 2, 3, 5 years of extensive SCLC were 17.0% (15/88), 10.2% (9/88), 0% (0/88), 0% (0/88). The 1, 3, 5-year survival rates of the “surgery + chemotherapy / radiotherapy group” and the “chemotherapy + surgery + chemotherapy / radiotherapy group” patients increased compared with those of the “ The difference was significant (P <0.05); the survival at 3 and 5 years was significantly higher than that of ”chemotherapy + surgery + chemotherapy / radiotherapy group“ and ”surgery + chemotherapy / radiotherapy group" P <0.05). 【Conclusion】 Extensive stage small cell lung cancer has no chance of surgical treatment, using simple / conservative treatment of radiotherapy. The combined treatment group, including surgery, with limited duration of small cell lung cancer is superior to the simple / radiotherapy group, with preoperative adjuvant chemotherapy is beneficial and feasible.