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随着呼吸管理的进步,在 ICU、急救医学及高压氧仓等方面应用高浓度高分压的氧疗法的机会增多。但对氧中毒的发生机理,至今尚未阐明。本文仅就氧中毒的指标(主要是肺、中枢神经系统)、发病机理和最近研究的动向加以概述。氧中毒的特征临床上在海拔平面条件(1 ATA)下,吸入高浓度氧时的并发症,有肺的变化(Lorrrain-Smith 效应)和早产儿视网膜症,以及高压下对中枢神经系统的影响(Paul Bert 效
As respiratory management advances, there is an increased chance of applying high concentrations of high partial pressure oxygen therapy in ICU, emergency medicine and hyperbaric oxygen chambers. However, the mechanism of occurrence of oxygen poisoning has not yet been clarified. This article summarizes only the indicators of oxygen toxicity (mainly the lungs and the central nervous system), their pathogenesis and recent trends in research. Characteristics of Oxygen Poisoning Complications of clinically elevated altitude oxygen (Lorrrain-Smith effect) and retinopathy of prematurity at high altitude under clinically normal altitude at 1 ATA and effects on CNS at high pressure (Paul Bert effect