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研究疏肝理气、利胆消积中药──熊胆复方粉的疏泄肝胆汁与促胆总管活动作用,自研制熊胆复方采用家兔开腹插管引流胆汁方法,选熊去氧胆酸(UDCA)作平行对照药,观察了两药用药前后家兔的胆汁流量与胆总管动作电位影响(反映胆总管活动情况)。结果表明:熊胆复方粉的作用明显优于UDCA片,统计结果P<0.01。提示熊胆复方有良好的促肝脏分泌疏泄胆汁与胆总管活动作用,为防治肝郁气滞、胆汁淤积所致的疾病提供了药效学依据,佐证了“肝合胆”的理论。
To study the effects of Shuganliqi and Xidanxiaoji, a traditional Chinese medicine known as Xiongdan compound powder, on the bile and hepatic bile and common bile duct tract mobilization. The self-developed bear gall bladder compound was prepared by a rabbit open and intubated drainage bile method and ursodeoxycholic acid was selected. (UDCA) was used as a parallel control drug to observe the effects of bile flow and common bile duct action potentials (reflecting common bile duct activity) before and after administration of the two drugs. The results showed that the effect of Xiongdan compound powder was significantly better than that of UDCA tablets, and the statistical result was P<0.01. It is suggested that the bear gall bladder compound has a good role in promoting the secretion of bile and common bile ducts in the liver, and provides pharmacodynamic basis for preventing and treating diseases caused by liver qi stagnation and cholestasis, supporting the theory of “hepatobiliary and gallbladder.”