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乙型肝炎是由乙型肝炎病毒(HBV)引起的严重危害人类健康的传染病。它不仅造成众多的HBV阳性携带者,也是导致成人慢性肝炎、肝硬化、肝癌的重要因素,我国是乙型肝炎病毒(HBV)感染的高发区,约有1.2亿人,资料表明有30%～50%HBV感染者源于母婴垂直传播[1]。近年国内外不少学者对阻断HBV母婴传播进行大量的研究,并提出可靠的阻断措施,但仍有15%～25%的失败率。本文对HBV宫内感染的机制和阻断效果的研究现状进行综合报道,为探讨更有效的阻断方法提供参考信息。
Hepatitis B is an infectious disease caused by Hepatitis B virus (HBV) that seriously endangers human health. It not only caused a large number of HBV-positive carriers, but also caused an important factor of chronic hepatitis, cirrhosis and liver cancer in adults. Our country is a high incidence area of hepatitis B virus (HBV) infection, with about 120 million people. The data shows that 30% 50% of HBV-infected persons are due to vertical transmission of mother to child [1]. In recent years, many scholars at home and abroad to block the mother-to-child transmission of HBV to conduct a lot of research, and put forward reliable blocking measures, but still 15% to 25% failure rate. This article comprehensively reports the current status of HBV intrauterine infection mechanism and blocking effect, providing reference information for exploring more effective blocking methods.