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缺氧诱导因子家族(HIFs)是细胞传递缺氧信号并引发“缺氧效应”的关键分子,HIFs的表达促进肿瘤的发生、发展和转移。在胶质瘤中,抑癌基因的失活促进HIFs的表达,HIFs还可以诱导肿瘤中癌基因的表达,促进血管生成,促进肿瘤干细胞形成并抑制其分化,降低肿瘤对放化疗的敏感性,探讨了HIFs在胶质瘤治疗中的前景。
Hypoxia-inducible factor family (HIFs) are key molecules that transmit hypoxia signals and initiate “hypoxia effect”. The expression of HIFs promotes the development, development and metastasis of tumors. In glioma, the inactivation of tumor suppressor gene promotes the expression of HIFs. HIFs can also induce the expression of oncogenes in tumor, promote angiogenesis, promote the formation of tumor stem cells and inhibit their differentiation, reduce the sensitivity of tumor to radiotherapy and chemotherapy, The prospect of HIFs in the treatment of glioma was discussed.