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目的:探讨肺感染患者多肿瘤标志物的变化及临床意义。方法:采用C12检测20例老年肺感染合并胸水患者、25肺感染无胸水患者、30例无肺部病变健康人12种肿瘤标志物水平。结果:肺感染无胸水组、肺感染合并胸水组血清ferritin浓度均显著高于对照组(P均<0.01),而这两组间差异无统计学意义。合并胸水组的血清CA125、CA15-3浓度均显著高于对照组和肺感染无胸水组(P<0.05,P<0.01),而对照和肺感染无胸水组间这两个指标比较无显著差异。其它指标各组间比较均无显著差异。肺感染合并胸水组,胸水中ferritin、CA125的浓度分别为281.3±103.2和389.1±71.1,均显著高于对应病例血清水平(P均<0.01)。血清与胸水间只有ferritin有相关性r=0.537,P<0.05。结论:肺感染患者血清某些肿瘤标志物异常,其血清浓度升高与胸水生成有关。
Objective: To investigate the changes and clinical significance of multiple tumor markers in patients with lung infection. Methods: C12 was used to detect the levels of 12 tumor markers in 20 elderly patients with pulmonary infection and pleural effusion, 25 patients with lung infection without pleural effusion and 30 patients without lung disease. Results: The concentration of serum ferritin in lung infection without pleural effusion group and lung infection combined with pleural effusion group were significantly higher than those in control group (all P <0.01), but there was no significant difference between the two groups. The serum concentrations of CA125 and CA15-3 in the combined pleural effusion group were significantly higher than those in the control group and pulmonary infection without pleural effusion (P <0.05, P <0.01), while there was no significant difference between the control and pulmonary pleural effusion without effusion . Other indicators no significant difference between the groups. The concentrations of ferritin and CA125 in pleural effusion group and pleural effusion group were 281.3 ± 103.2 and 389.1 ± 71.1, respectively, which were significantly higher than those of the corresponding cases (all P <0.01). Only ferritin between serum and pleural effusion was associated with r = 0.537, P <0.05. Conclusion: Some of the serum tumor markers in patients with lung infection are abnormal. The serum concentration is correlated with the formation of pleural effusion.