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常规的单一或联合化疗治疗晚期恶性黑素瘤诱导缓解期很短,而且只有极少数病例治愈。为了提高疗效,必须寻找新的疗法。本文简要地综述了干扰素单一疗法、细胞因子联合疗法(包括干扰素和化疗药物联合应用)、外源性免疫疗法和白细胞介素的应用、体液免疫疗法(单克隆抗体)和特异性免疫疗法(如同种异体肿瘤溶解物的应用)。并对上述诸疗法的疗效、作用机制及应注意的问题进行了讨论。
Conventional single or combined chemotherapy for the treatment of advanced malignant melanoma has a short induction period and is only rarely cured. In order to improve the efficacy, new treatments must be found. This article briefly reviews interferon monotherapy, cytokine combination therapy (including interferon and chemotherapeutic agents), exogenous immunotherapy and interleukin use, humoral immunotherapy (monoclonal antibodies) and specific immunotherapy (like the application of allogeneic tumor lysates). The efficacy, mechanism of action, and issues that should be noted for these various therapies are discussed.