苯扎贝特(bezafibrate)是一种降血脂药物,本文报道一例由此药致头痛的患者。患者为患高脂血症(Ⅱ_a型,家族性特发性高胆固醇血症)数年的女性,并伴有血清阴性多关节炎。为维持双氯芬酸血浓度于晚上用100mg早上用50mg,结果出现症状改善,无副反应。因规定饮食不足以控制患者的高脂血症,1个月后,即始用苯扎贝特200mg/d(分三次)。但于第4次用药后约1h,患者出现严重的复发性头痛。头痛为搏动性 Bezafibrate is a hypolipidemic drug, and we report a case of headache caused by this drug. Patients were hyperlipidemic (type IIa, familial idiopathic hypercholesterolemia) for several years in women with seronegative polyarthritis. In order to maintain diclofenac blood concentration in the evening with 100mg 50mg in the morning, the results showed improved symptoms, no side effects. Because of the lack of diet to control the patient’s hyperlipidemia, Bezafibrate 200 mg / d (in three doses) is given after 1 month. However, about 4 hours after the 4th dose, the patient developed severe recurrent headache. Headache is pulsatile