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目的 探讨遗传性非息肉病性大肠癌 (HNPCC)肠外肿瘤的特点。方法 对随访登记的 32家系进行随访和回顾。结果 在 12个典型HNPCC家系中 ,6家系发生 8例肠外肿瘤 ,2 0家系非典型的HNPCC家系中 ,1家族中有 1例肠外肿瘤发生 ,肠外肿瘤最常见为子宫内膜癌和胃癌。结论 大肠外肿瘤为HNPCC肿瘤谱中的重要成员 ,中国人的大肠外肿瘤胃癌、子宫内膜癌较多见。
Objective To investigate the characteristics of extraintestinal neoplasms in hereditary nonpolyposis colorectal cancer (HNPCC). Methods Follow-up and review of the 32 families with follow-up registration. Results Among the 12 typical HNPCC families, 8 cases had 8 cases of extra-intestinal tumors, 20 cases of atypical HNPCC families, 1 case had 1 cases of extra-intestinal tumors, extra-intestinal tumors were most common for endometrial cancer and Gastric cancer. Conclusion Extra-intestinal tumors are an important member of the HNPCC tumor spectrum. Chinese extra-intestinal tumors are more common in gastric and endometrial cancers.