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目前认为环境致癌物的体内代谢及随后的活化涉及氧化酶系统,并与多种药物的代谢作用相同。已证实异哇胍与其代谢产物羟基异哇胍在尿中的比例有大、中、小3种分布,其中纯合子大量代谢产物型者患癌的危险性显著增高,这可能与环境致癌物在机体组织内被活化的浓度较高有关。据美沙芬(DMP)的脱甲基与异哇胍的4-羟基化作用相似,作者对健康人和肺癌患者进行美沙芬试验,以探讨其对肺癌遗传素质的意义。
It is currently believed that the in vivo metabolism and subsequent activation of environmental carcinogens involves an oxidative enzyme system and is identical to the metabolism of many drugs. It has been confirmed that the proportion of isoamylase and its metabolite hydroxyisoammonium in urine is large, medium, and small, and homozygous metabolites have a significantly higher risk of cancer, which may be related to environmental carcinogens. It is related to the higher concentration of activated body tissue. According to the similarity between the demethylation of dextromethorphan (DMP) and 4-hydroxylation of isoamyloxime, the authors conducted a MSF trial on healthy people and lung cancer patients to explore its significance for the genetic quality of lung cancer.