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目的探讨新生儿细菌感染及抗生素的临床应用情况。方法对隆林县人民医院2010年1月～2011年12月期间收治的341例新生儿细菌感染患儿病例资料进行回顾性分析,同时对抗生素使用情况进行回顾性总结。结果 341例新生儿细菌感染表现肺炎189例(占55.43%),脐炎78例(占22.87%),结膜炎62例(占18.18%),鹅口疮6例(占1.76%),尿路感染4例(占1.17%),化脓性脑炎1例(占0.29%),脓疱疹1例(占0.29%;341例新生儿在治疗中抗生素的使用率为100%,使用频率名次前三位是青霉素(84.75%)、氨苄青霉素(62.17%)、苯唑青霉素(29.62%),其中青霉素在新生儿细菌感染中使用频率最高,和其他抗生素相比具有显著性差异,P<0.05,有统计学意义,联合使用两种以上抗生素的108例,占31.67%。结论对于新生儿细菌感染病例,要严格的掌握抗生素使用规则,避免联合用药,并对预防性抗生素应用进行严格控制。
Objective To investigate the clinical application of bacterial infection and antibiotics in neonates. Methods A retrospective analysis was made on the data of 341 cases of neonates with bacterial infection admitted to Longlin County People’s Hospital from January 2010 to December 2011 and retrospectively reviewed about the antibiotic use. RESULTS: The bacterial infections of 341 newborn infants showed 189 cases (55.43%) of pneumonia, 78 cases (22.87%) of omphalitis, 62 cases (18.18%) of conjunctivitis, 6 cases of thrush (1.76%), urinary tract infection 4 cases (accounting for 1.17%), purulent encephalitis in 1 case (0.29%) and impetigo in 1 case (0.29%); 341 newborns were treated with 100% antibiotics and the top three frequencies Penicillin (84.75%), ampicillin (62.17%), oxacillin (29.62%), of which penicillin in neonatal bacterial infection in the highest frequency, and other antibiotics compared with significant differences, P <0.05, there are statistics Significance, combined use of two or more antibiotics in 108 cases, accounting for 31.67% .Conclusion In neonatal cases of bacterial infections, strict rules of antibiotics, to avoid the combination of drugs, and the application of preventive antibiotics strictly controlled.