论文部分内容阅读
片剂、胶囊的崩解和溶出速率的关系是一致的。实验资料已证明,在相同的仪器条件下,崩解和溶出是相关的。对此,Wagner首先指出:应该用一级动力学的观点来分析溶出的数据。Carstensen等认为所有的溶出和崩解数据都遵循着指数减少的规律。Kita-zawa等人公布了与Wagner相似的方程式,该式不考虑溶质微粒的表面积而是进一步考虑溶出数据,以半对数对时间作图,得到两条直线,这两条直线的相交点就是片剂崩解成微粒的时间。Nelson和Wang描述了确定片剂崩解时间的方法,用数学分析了片剂实验溶出图和药物颗粒的原始特征。EI-Yazigi
The disintegration and dissolution rates of tablets, capsules are consistent. Experimental data have demonstrated that disintegration and dissolution are relevant under the same instrumental conditions. In this regard, Wagner first pointed out: should be a kinetic point of view to analyze the dissolution of the data. Carstensen and others think that all the dissolution and disintegration data follow the law of exponential reduction. Kita-zawa et al. Have published a similar equation to Wagner, which considers the surface area of solute particles rather than the dissolution data, plotting the half logarithm versus time, resulting in two straight lines, the intersection of which is The time it takes for tablets to disintegrate into granules. Nelson and Wang describe a method of determining tablet disintegration time that mathematically analyzes the original characteristics of tablet experimental dissolution maps and drug particles. EI-Yazigi