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目的分析临床分离的碳青霉烯类抗生素耐药革兰阴性杆菌对替加环素药物的敏感性。方法收集临床分离的碳青霉烯类抗生素耐药革兰阴性杆菌52株,其中鲍曼不动杆菌36株,肠杆菌科细菌16株。采用K-B纸片扩散法测定菌株对常规药物的敏感性,采用替加环素最小抑菌浓度测试条对以上菌株进行测定,并分析其敏感性。结果 52株碳青霉烯类耐药革兰阴性杆菌对常规药物呈现出多重耐药表型,仅对很少药物具有一定的敏感性。其中鲍曼不动杆菌对阿米卡星敏感率为36.1%,对头孢哌酮/舒巴坦的敏感率为14.0%;肠杆菌科细菌对复方新诺明的敏感率为37.5%,对阿米卡星敏感率为25.0%。36株鲍曼不动杆菌中替加环素敏感5株(13.9%),中介22株(61.1%),耐药9株(25.0%);16株肠杆菌科细菌对替加环素全部敏感(100%)。结论本院分离碳青霉烯类耐药革兰阴性杆菌对常规药物呈现多重耐药表型。碳青酶烯类耐药肠杆菌科细菌对替加环素敏感性较高,鲍曼不动杆菌则表现为中介和耐药居多。
Objective To analyze the sensitivity of clinical isolates of carbapenem-resistant gram-negative bacilli to tigecycline. Methods 52 clinical isolates of carbapenem-resistant Gram-negative bacilli were collected, including 36 strains of Acinetobacter baumannii and 16 strains of Enterobacteriaceae. The K-B disk diffusion method was used to determine the sensitivity of the strains to conventional drugs. The test strains with the minimum inhibitory concentration of tigecycline were used to determine the above strains and their sensitivity was analyzed. Results Fifty-two carbapenem-resistant Gram-negative bacilli showed multi-drug resistant phenotypes to conventional drugs and were only sensitive to a few drugs. Among them, Acinetobacter baumannii sensitivity was 36.1%, cefoperazone / sulbactam sensitivity rate was 14.0%; Enterobacteriaceae bacteria sensitivity to cotrimoxazole was 37.5% Mika star sensitive rate of 25.0%. Among 36 strains of Acinetobacter baumannii, 5 strains of tigecycline were sensitive (13.9%), 22 strains (61.1%) were mediators and 9 strains were resistant (25.0%). 16 strains of Enterobacteriaceae were all sensitive to tigecycline (100%). Conclusion The carbapenem-resistant Gram-negative bacilli in our hospital showed multi-resistant phenotype to conventional drugs. Carbapenems-resistant Enterobacteriaceae are more susceptible to tigecycline and Acinetobacter baumannii is mostly intermediate and resistant.