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生殖细胞肿瘤是指起源于胚胎性腺中原始生殖细胞的一组不同组织学类型的肿瘤,包括精原细胞瘤、无性细胞瘤、卵黄囊瘤、胚胎性癌、绒毛膜癌和畸胎瘤等。八聚体结合转录因子4(octamer-binding transcription factor4,Oct-4)是 POU转录因子家族中的一个成员,它在生殖细胞肿瘤中高度表达,是一种生殖细胞肿瘤的标志物。目前,Oct-4的作用机理并不十分清楚,因此,对于 Oct-4的进一步研究,将有助于解决与生殖细胞肿瘤的诊断、鉴别诊断以及治疗相关的一系列
Germ cell tumor refers to a group of tumors of different histological types originating from primordial germ cells in embryonic gonads, including seminoma, dysgerminoma, yolk sac, embryonal carcinoma, choriocarcinoma and teratoma. Octamer-binding transcription factor 4 (Oct-4), a member of the POU transcription factor family, is highly expressed in germ cell tumors and is a marker of germ cell tumors. At present, the mechanism of action of Oct-4 is not very clear, so further research on Oct-4 will help to solve a series of related germ cell tumors diagnosis, differential diagnosis and treatment