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肺炎球菌多糖蛋白结合疫苗可诱导抗多糖抗体 ,但需多剂免疫才能使儿童达到保护性抗体水平。实验性多价肺炎球菌多糖蛋白结合疫苗的免疫原性随多糖血清型不同而异。提高这些疫苗免疫原性的一种策略是掺入佐剂。含非甲基化 Cp G基元的合成寡脱氧核苷酸 ( Cp G ODN)作为佐剂能促进
The pneumococcal polysaccharide protein conjugate vaccine induces anti-polysaccharide antibodies, but multiple doses of immunization are required to reach the level of protective antibodies in children. The immunogenicity of the experimental multivalent pneumococcal polyclonal protein conjugate vaccine varies with polysaccharide serotypes. One strategy to increase the immunogenicity of these vaccines is to incorporate adjuvants. Synthetic oligodeoxynucleotides containing unmethylated CpG motifs (CpG ODNs) are promoted as adjuvants