肥胖已经成为世界性的疾病,严重危害人类健康和生命,而肥胖诱导的代谢性炎症进一步促使代谢并发症的发生。脂肪组织作为一个内分泌器官,可分泌多种脂肪细胞因子(adipokines),包括脂肪细胞特异性蛋白(如脂联素、瘦素)、炎性趋化因子(如肿瘤坏死因子-α)、各种白细胞介素、血管紧张素Ⅱ等[1-2]。而锌α2糖蛋白(zinc-α2-glycoprotein,ZAG)作为一种新型的脂肪细胞因子,在预防和治疗肥胖及代谢性疾病方面,越来越受到人们的关注。 Obesity has become a worldwide disease, seriously endangering human health and life, and obesity-induced metabolic inflammation further promote the occurrence of metabolic complications. As an endocrine organ, adipose tissue secretes a variety of adipokines, including adipocyte-specific proteins (such as adiponectin, leptin), inflammatory chemokines (such as tumor necrosis factor-α), various Interleukin, angiotensin Ⅱ [1-2]. As a new type of adipocytokines, zinc-α2-glycoprotein (ZAG) has drawn more and more attention in preventing and treating obesity and metabolic diseases.