阿朴啡生物碱是异喹啉生物碱中仅次于苯甲基异喹啉类的第二大类生物碱［１］，其基本结构如图１所示。许多这类生物碱化合物具有重要的生理活性，如月桂叶碱（Ｃａｕｎｆｏｌｉｎ）盐酸盐具有降血压的活性［２］，木兰碱Ｆｉｇ．１具有血管紧张素Ⅱ受体拮抗活性。因此，这类化 Aporphine alkaloids is the second largest alkaloid in isoquinoline alkaloids, which is second only to benzyl isoquinolines [1]. Its basic structure is shown in Fig.1. Many of these alkaloid compounds have important physiological activities, such as the hypotensive activity of Caunfolin hydrochloride [2], magnoliane Fig. 1 has angiotensin II receptor antagonistic activity. Therefore, this type of