Large-scale multicommodity facility location problems are generally intractable with respect to standard mixed-integer programming (MIP) tools such as the direct application of general-purpose Branch & Cut (BC) commercial solvers i.e. CPLEX. In this paper, the authors investigate a nested partitions (NP) framework that combines meta-heuristics with MIP tools (including branch-and-cut).We also consider a variety of alternative formulations and decomposition methods for this problem class. Our results show that our NP framework is capable of efficiently producing very high quality solutions to multicommodity facility location problems. For large-scale problems in this class, this approach is significantly faster and generates better feasible solutions than either CPLEX (applied directly to the given MIP) or the iterative Lagrangian-based methods that have generally been regarded as the most effective structure-based techniques for optimization of these problems. We also briefly discuss some other large-scale MIP problem classes for which this approach is expected to be very effective.