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在他汀治疗使低密度脂蛋白胆固醇(LDL-C)达标的后,对高密度脂蛋白胆固醇(HDL-C)降低的患者加用烟酸,可以升高HDL-C并降低甘油三酯,显著改善血脂谱。尽管小规模临床试验显示在他汀基础上联合烟酸可以延缓冠状动脉斑块或颈动脉内膜中层厚度的进展,但他汀联合烟酸的疗效至今仍然没有在大规模临床试验中得到证实。单纯升高HDL-C血浆水平而不关注HDL-C的清除是目前针对HDL-C干预治疗的问题所在,他汀联合烟酸的有效性和安全性有待于进一步证实。
Adding niacin to patients with reduced HDL-C after statin treatment of LDL-C achieved an increase in HDL-C and a decrease in triglycerides, notably in patients with low-density lipoprotein cholesterol (HDL-C) Improve blood lipid profile. Although small-scale clinical trials have shown that statin-based niacin supplementation can delay the progression of coronary plaque or carotid artery intima-media thickness, the efficacy of statins combined with niacin has not yet been demonstrated in large-scale clinical trials. Simply raising the HDL-C plasma level without concern for the clearance of HDL-C is the current treatment of HDL-C problems, the efficacy and safety of statin combined with niacin needs to be further confirmed.