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目的 探讨食管癌Fhit蛋白表达与临床病理的关系。方法 采用免疫组化方法 ,检测 5 3例食管癌Fhit表达并分析其与组织学分级、临床分期的关系。结果 癌组织Fhit表达为 2 3/ 5 3例 (43.4 % ) ,而癌旁非肿瘤粘膜为 4 7/ 5 3例 (88.7% ) ,相差有非常显著性 (P <0 .0 0 1)。Fhit蛋白表达癌在癌组织学分级中的分布为Ⅰ级癌 5 5 .6 % (5 / 9) ,Ⅱ级癌 4 0 .6 % (13/ 32 ) ,Ⅲ级癌 4 1.7% (5 / 12 ) ,相差无显著性 (P >0 .0 5 )。Fhit蛋白表达癌在临床分期中的分布为Ⅰ期癌 77.8% (7/ 9) ,Ⅱ期癌 4 2 .9% (15 / 35 ) ,Ⅲ期癌 11.1% (1/ 9) ,相差有非常显著性 (P <0 .0 0 1)。结论 Fhit表达状况可能与食管癌的侵犯和转移相关
Objective To investigate the relationship between Fhit protein expression and clinical pathology in esophageal cancer. Methods Immunohistochemical method was used to detect the expression of Fhit in 53 cases of esophageal carcinoma and to analyze its relationship with histological grade and clinical stage. Results The expression of Fhit was 23/53 (43.4%) in cancerous tissues, while 47 of 5 (88.7%) adjacent noncancerous mucosa had a significant difference (P <0.01). The distribution of Fhit protein in the histological grading of carcinoma was grade Ⅰ carcinoma (5.56%, 3/6), grade Ⅲ carcinoma (4.36%), grade Ⅲ carcinoma 12), no significant difference (P> 0.05). The distribution of Fhit protein in clinical staging was 77.8% (7/9) in stage Ⅰ carcinoma, 42.9% (15/35) in stage Ⅱ carcinoma and 11.1% (1/9) in stage Ⅲ carcinoma, with a significant difference Significance (P <0. 001). Conclusion The expression of Fhit may be related to the invasion and metastasis of esophageal cancer