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目的观察甘氨双唑钠(CMNa)对Ⅲ期非小细胞肺癌(NSCLC)三维适形放疗(3-DCRT)的放射增敏作用及其安全性。方法经病理和细胞学证实的Ⅲ期NSCLC病人32例,随机分为试验组16例和对照组16例,对照组采用全身伽玛刀放疗,每周5次,每次3·5GY,总剂量为70GY。试验组在每次全身伽玛刀放疗前使用CMNa800mg/m-2。结果CR率试验组为62·5%,对照组为18·8%,两组比较差异有统计学意义(P=0·02901);总有效率试验组为100%,对照组为75%,但无统计学意义(P>0·05);试验组病人治疗达到PR和CR时的中位照射剂量均低于对照组,放射增敏比(SER值)分别为1·20和1·33。主要毒副反应为RTOG1~2级放射性食管炎和放射性肺炎,两组发生率比较均无统计学意义(P>0·05)。结论CMNa对Ⅲ期非小细胞肺癌三维适形放疗有较肯定的放射增敏作用,明显提高了NSCLC的近期疗效,且安全,不增加毒副反应。
Objective To observe the radiosensitizing effect and safety of glycididazole sodium (CMNa) on three-dimensional conformal radiotherapy (Ⅲ-DCRT) in stage Ⅲ non-small cell lung cancer (NSCLC). Methods Thirty-two NSCLC patients confirmed by pathology and cytology were randomly divided into experimental group (n = 16) and control group (n = 16). The control group was treated with whole body gamma knife radiotherapy 5 times a week for 3.5 Gy, For 70GY. The test group received CMNa 800 mg / m-2 before each Gamma Knife radiotherapy. Results The CR rate was 62.5% in the trial group and 18.8% in the control group, with significant difference between the two groups (P = 0.02291). The total effective rate was 100% in the trial group and 75% in the control group. But no statistical significance (P> 0.05). The median radiation dose of PR and CR in treatment group was lower than that in control group, and the SER values were 1.20 and 1.33 . The main toxicities were RTOG1 ~ 2 esophagitis and radiation pneumonitis, the incidence of the two groups were not statistically significant (P> 0.05). Conclusion CMNa has certain positive radiosensitization effect on the three-dimensional conformal radiotherapy of stage Ⅲ non-small cell lung cancer, significantly improves the short-term curative effect of NSCLC, and is safe and does not increase the side effects.