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目的 :探讨相同的三联疗法 ,不同的治疗方案对相同疾病的疗效及所产生经济效果的差别。方法 :根据文献选择 2 32例幽门螺杆菌 (Hp)阳性病人 ,采用相同的三联疗法 ,六种不同的方案。 (A1组 :奥美拉唑 (2周 ) +克拉霉素 +阿莫西林 ,疗程 1周 ;A2 组药物同A1组 ,疗程 2周 ;B1组 :只克拉霉素加倍剂量 ,其它药物同A1组 ,疗效 1周 ;B2 组 :药物同B1组 ,疗程 2周 ;C1组 :奥美拉唑 (2周 ) +阿莫西林 +甲硝唑 ,疗程 1周 ;C2 组 :药物同C1组 ,但阿莫西林 +甲硝唑疗程加倍 )。运用药物经济学的成本 -效果分析方法进行评价。结果 :A1、A2 、B1、B2 、C1、C2 6种方案中的总成本为 1819.98、2 0 5 4.76、2 0 2 6 .2 0、2 46 7.2 0、16 14.71、16 44 .2 2元 ;其效果Hp根除率分别为 :90 .5 0 %、89.5 0 %、88.2 0 %、94.2 0 %、6 7.5 0 %、87.5 0 %。溃疡愈合率分别为 :92 .90 %、94.70 %、94.10 %、94.2 0 %、85 .0 0 %、90 .6 0 %。结论 :A1方案为最佳治疗方案。
Objective: To explore the same triple therapy, different treatment options for the same disease efficacy and economic effects produced by the difference. Methods: According to the literature, 2 32 H. pylori (Hp) positive patients were selected and treated with the same triple therapy and six different regimens. (Group A1: omeprazole (2 weeks) + clarithromycin + amoxicillin for 1 week; Group A2 was given the same treatment as Group A1 for 2 weeks; Group B1: double the amount of clarithromycin only, other drugs were the same as A1 Group B2, the drug group with B1, treatment for 2 weeks; C1 group: omeprazole (2 weeks) + amoxicillin + metronidazole for 1 week; group C2: drug with C1 group, But amoxicillin + metronidazole doubled). Use cost-effectiveness analysis of pharmacoeconomics to evaluate. Results: The total cost of the six schemes of A1, A2, B1, B2, C1 and C2 is 1819.98, 2 0 5 4.76, 2 0 2 6 .2 0,2 46 7.2 0,16 14.71,16 44 .2 2 yuan The effective rate of Hp eradication was 90.5%, 89.5%, 88.2%, 94.2%, 67.5% and 87.5% respectively. The rates of ulcer healing were 92.90%, 94.70%, 94.10%, 94.2%, 85.0%, 90.60%, respectively. Conclusion: A1 is the best treatment option.